The preserve is a popular destination for boating, fishing, kayaking and nature appreciation, such as bird-watching. St. Lucie Inlet State Park is only accessible by boat, but its quiet beaches are great for swimming, sunbathing, picnicking and surf fishing. Marinas, boat ramps and local parks also offer access to the preserve. The spoil islands of the preserve are popular destinations for picnicking and camping.

• St. Lucie Inlet State Park

Indian River Lagoon is also part of the Florida Circumnavigational Saltwater Paddling Trail. Jensen Beach to Jupiter Inlet Aquatic Preserve spans two segments of the paddling trail.

• Palm Beach / Loxahatchee
• Hobe Sound / Ft. Pierce