The preserve is a popular destination for boating, fishing, kayaking and appreciating nature. Sebastian Inlet State Park, which borders the preserve, has boat launches and a non-motorized boat launch for kayaks, canoes and sailboats. It's also a popular destination for swimming and sunbathing. Manatees can be seen congregating in St. Sebastian River State Park from November to March in the C54 Canal.

• Sebastian Inlet State Park
• St. Sebastian River Preserve State Park